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A recentlarge observational cohort data (n = 57,039) suggests that theadministration of morphine may be associated with an increasedrisk of mortality.19 Patients who received morphine within thisregistry (29.8%) had a higher risk-adjusted likelihood of all-causein-hospital death (OR 1.48) during treatment for ACS.

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It is highlyimpermeable to macromolecules and is considered a majorstructural component of the barrier within the cortical pa-renchyma. Other paraneoplastic syndromes include sub-acute sensory neuronopathy, demyelinating neuropathy(usually a feature of paraproteinemic malignancies; see thepreceding discussion in Paraproteinemic polyneuropathy),mononeuropathy multiplex, MND, and motor neuropathy.Paraneoplastic sensory neuropathy is characterized bynumbness, painful paresthesias, and lancinating pain. The severity of neurological deficits following meth-ylmercury poisoning is dependent upon the extent ofexposure as well as the age of the individual, with youngchildren and the fetus being significantly more susceptible toneuronal loss than adults.

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